SARS-CoV-2 infection in microglia and its sequelae: What do we know so far?

SARS-CoV-2 infection in microglia and its sequelae: What do we know so far?

Blog Article

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic.After the success of therapeutics and worldwide vaccination, the long-term sequelae of SARS-CoV-2 infections are yet to be determined.Common symptoms of COVID-19 include the loss of taste and smell, suggesting SARS-CoV-2 infection has a potentially detrimental effect on neurons within the olfactory/taste pathways, with direct access to the central nervous system (CNS).

This could explain the detection of SARS-CoV-2 antigens in the brains of COVID-19 patients.Different viruses display chicago cubs earrings neurotropism that causes impaired neurodevelopment and/or neurodegeneration.Hence, it is plausible that COVID-19-associated neuropathologies are directly driven by SARS-CoV-2 infection in the CNS.

Microglia, resident immune cells of the brain, are constantly under investigation as their surveillance role has been suggested to act as a friend or a foe impacting the progression of neurological disorders.Herein, we review the current literature suggesting microglia potentially been discount greenery a susceptible target by SARS-CoV-2 virions and their role in viral dissemination within the CNS.Particular attention is given to the different experimental models and their translational potential.